职 称:副教授
学 历:博士
E-mail:bszzhuhongda@yeah.net
研究方向:纳米医药,新型药物制剂
学习、工作经历:
教育经历:
2007-09- 2011-03,华中科技大学,生物制药工程,博士,导师:杨祥良教授;
2005-09 – 2007-06,武汉大学,药剂学,硕士,导师:张先洲副教授
1992-09 – 1996-06,华中科技大学同济医学院,药学,学士;
工作经历:
2011-06 -至今,湖北工业大学,beat·365(中国) - 官方网站,讲师至副教授
2016-03-2017-03,美国北卡罗纳大学教堂山,药学院,访问学者;
1996-08– 2005-07,湖北省荆州市中心医院,药学部,主管药师;
社会兼职:
湖北省药学会理事,湖北省药学会药剂专业委员会委员
研究课题:
1.湖北工业大学绿色工业科技引领计划-自主探索计划,纳米共输送体系的免疫微环境多重调控策略在三阴性乳腺癌免疫治疗中的增效作用探索,2022.01-2023-12/10万、在研、主持。
2.中国临床肿瘤学会(CSCO)-恒瑞肿瘤研究基金项目,基于肿瘤免疫微环境调控的新化疗-免疫联合治疗方案在三阴性乳腺癌的应用基础研究,Y-HR2019-0325,2020.11-2022.12、在研、主持。
3.国家自然科学基金青年项目,81201197、还原敏感触发式纳米Pickering乳递药系统的构建及靶向肝癌的研究、2013.01-2015.12、23万、结题、主持。
4.国家自然科学面上基金,51371079,金属纳米周期结构与石墨烯复合体系的构筑及其在表面增强拉曼散射(SERS)中的应用、2014.1-2018.12、79万、结题、参加。
5.湖北省自然科学基金项目,2015CFB588、还原响应的壳交联聚合物胶束用于阿霉素的高效包载和靶向控制释放、2015/01-2017/10、3万、结题、主持。
6.湖北省自然科学基金重点项目,2014CFA080,模块化构建精确控释的化学-光热疗法纳米药物及其靶向肿瘤研究,2014/12-2017/12、10万元、结题、参加。
研究成果:
1)Huocheng Yang, Le Tu, Jie Li, Suya Bai, Zongxing Hu, Peng Yin, Huiyu Lin, Qi Yu*,Hongda Zhu*, Yao Sun*, Deep and precise lighting-up/combat diseases through sonodynamic agents integrating molecular imaging and therapy modalities, Coordination Chemistry Reviews, Volume 453, 2022: 214333.
2)Zilin Zhang, Kai Ma1,Jing Li, Yeneng Guan, Chaobo Yang, Aqing Yan,Hongda Zhu*, The clinical value of chemotherapy combined with capecitabine in triple-negative breast cancer—A meta-analysis. Frontiers in Pharmacology, 2021,12: 771839.
3)Xiaodi Xu, Zihan Dai, Ziling, Zhang, Xianyong Kou, Xiangyu You, Hongmei Sun, Huiling Guo, Mingxing Liu,Hongda Zhu*, Fabrication of oral nanovesicle in-situ gel based on Epigallocatechin gallate phospholipid complex: Application in dental anti-caries. European Journal of Pharmacology, 2021, 897, 173951.
4)Tang Qin, Zhu Dai*, Xiaodi Xu, Ziling, Zhang, Xiangyu You, Hongmei Sun, Mingxing Liu,Hongda Zhu*. Nanosuspension as an Efficient Carrier for Improved Ocular Permeation of Voriconazole. Current Pharmaceutical Biotechnology, 2021, 22(2): 245 - 253.
5)Tang qin, xiaodi xu, zilin Zhang, jing li, xiangyu you, huilin guo, hongmei sun, mingxing liu, zhu dai,Hongda Zhu*,Paclitaxel/sunitinib-loaded micelles promote an antitumor response in vitro through synergistic immunogenic cell death for triple-negative breast cancer, Nanotechnology,2020, 31:365101.
6)Hongda Zhu#, Qi Liu#, Lei Miao, Sara Musetti, Meirong Huo, Leaf Huang*, Remodeling the fibrotic tumor microenvironment of desmoplastic melanoma to facilitate vaccine immunotherapy, Nanoscale, 2020, 12(5): 3400-3410.(共同第一作者)
7)Xingxing Shang; Qi Liu; Tang Qin; Xiaodi Xu; Hongmei Sun; Mingxing Liu;Hongda Zhu*, Fabrication of cRGD-modified reduction-sensitive nanocapsule via Pickering emulsion route to facilitate tumor-targeted delivery, International Journal of Nanomedicine, 2019, 14: 3361-3373.
8)Qi Liu#,Hongda Zhu#, Karthik Tiruthani, Limei Shen, Fengqian Chen, Keliang Gao, Xueqiong Zhang, Lin Hou, Degeng Wang, Rihe Liu, Leaf Huang*, Nanoparticle-Mediated Trapping of Wnt Family Member 5A in Tumor Microenvironments Enhances Immunotherapy for B-Raf Proto-Oncogene Mutant Melanoma, ACS Nano, 2018, 12(2): 1250~1261.(共同第一作者)